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    Il presente articolo sul Sildenafil riporta le informazioni che è possibile reperire sul foglietto illustrativo del prodotto commerciale o sul sito della casa produttrice e dagli studi medici in bibliografia, non intende pubblicizzarne l'uso o promuoverlo in nessun modo, si ricorda di avere sempre la supervisione di un medico e di attenersi alle sue indicazioni, altresì le informazioni potrebbero essere non aggiornate per cui si consiglia di recarsi dal proprio medico o farmacista per ulteriori informazioni, inoltre si raccomanda di non fare acquisti su internet per la pericolosità di presunte farmacie e soprattutto senza un medico. Avere Possiamo dire come informazione primaria che Sildenafil agisce sulle strutture vascolari del pene, i cosiddetti "corpi cavernosi", favorendo l'afflusso di sangue all'interno di essi e di conseguenza permettendo l'erezione. La compressa di Sildenafil va assunta possibilmente lontana dal pasto; dopo circa 50 minuti, una sufficiente concentrazione del farmaco Sildenafil raggiunge i corpi cavernosi ed in presenza di eccitazione l'erezione risulterà facilitata; l'efficacia ha una durata che può andare dalle 4 alle 6 ore. Il farmaco Sildenafil viene metabolizzato a livello epatico da due citocromi: il citocromo 3A4 ed il citocromo 2C9. Il principale metabolita ottenuto è l’N-demetil sildenafil il quale è ancora farmacologicamente attivo (è in grado di inibire le 5PDE con una potenza, rispetto al sildenafil, del 50). Il rilassamento dei muscoli lisci dei corpi cavernosi dovuto al Sildenafil è mediato dall’ossido di azoto (NO) che attiva l’enzima guanilato ciclasi che catalizza la trasformazione della guanosina trifosfato o GTP in guanosina monofosfato ciclico o c GMP che stimola il rilasciamento muscolare. Ecco alcuni possibili comuni effetti collaterali di Sildenafil : mal di testa, stomaco agitato, infezioni del tratto urinario, sensibilità aumentata ai colori verde e rosso, diarrea, altri problemi, etc. Take this tour of medicine's future with some of the trailblazing doctors charting its course. Once you've seen a transplantable human kidney created from a 3D printer, almost anything is imaginable ... The age of bioengineering is upon us, with scientists' understanding of how to engineer cells, tissues and organs improving at a rapid pace. Here, how this could affect the future of our physical bodies. by Siddhartha Mukherjee A Pulitzer Prize-winning author and one of the world’s premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine — and how understanding these principles can empower us all.

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