Millions of American adults suffer from major depressive disorder (MDD), a condition that often interferes with a person’s ability to work, carry on successful interpersonal relationships, and engage in daily activities of living. However, many people get relief from their depression by taking antidepressant medications. Popular classes of antidepressants include selective serotonin reuptake inhibitors, or SSRIs (among them sertraline, found in Zoloft), and serotonin and norepinephrine reuptake inhibitors, or SNRIs (among them venlafaxine, used in Effexor). “Depression is an illness, and, just like any other illness, it needs to be treated so that symptoms can be alleviated and complications can be prevented,” says Anna Rosen, MD, a psychiatrist at Weill Cornell Medicine. Rosen says that several factors are considered when choosing an antidepressant medication. A physician will first obtain a thorough medical and personal history and listen to the patient explain the symptoms he or she is having. Rosen considers which symptoms are causing the most distress and which medication is most likely to provide symptom relief, along with the possible side effects. “For example, a patient who is depressed and has problems sleeping needs a medication that will help improve sleep rather than one that might further disrupt sleep. Benzodiazepines, such as Valium and Xanax, interrupt sleep rhythm, but the antidepressants mirtazapine (Remeron) and trazodone often help improve sleep,” she explains. 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In two head-to-head comparison studies, people with major depression treated with Effexor venlafaxine were more likely to recover. Before day 1 gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is 50 mg/day. Day 1 reduce dosage of sertraline to 25. • Venlafaxine inhibits the reuptake of serotonin and norepinephrine in the brain. • The reuptake effects of venlafaxine are dose dependent. At low doses it blocks only serotonin neurotransmission. At higher doses venlafaxine blocks neurotransmission of both serotonin and noradrenaline. • Sertraline undergoes extensive hepatic metabolism by CYP enzymes. The drug is primarily metabolized by CYP3A4 to its active metabolite N-desmethylsertraline and several other metabolites. Nevertheless both sertraline and venlafaxine may lead to significant weight gain. • Discontinuation syndrome Sertraline may be associated with a lower symptom burden during treatment discontinuation Hot flashes and night sweats are common vasomotor symptoms during the peri- and early post-menopausal period. If you have suffered injuries or serious side effects caused by an antidepressant you are taking, you may have a defective product liability claim. (To learn more about drug related product liability claims in general, read Nolo's article Product Liability Claims Involving Pharmaceutical Drugs.) Many antidepressants are in a class of drugs called selective serotonin reuptake inhibitors ("SSRI's"). There are numerous SSRI's and other antidepressants currently on the market, including the following: In recent years, reports of serious side effects from taking antidepressant drugs have increased, and many lawsuits have been filed against drug manufacturers in connection with the side effects of antidepressants. The focus of these lawsuits is typically a products liability claim. In a products liability lawsuit, the plaintiff seeks compensation for injuries caused by a consumer product. When the injury-causing product is a pharmaceutical drug, the most common claims are that: Depending on the specific antidepressant you are taking, there may be other possible side effects. For example, Serzone has been the subject of an FDA warning concerning possible liver damage. Zoloft effexor What To Expect Switching From Zoloft to Effexor? 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