Tamoxifen and sleep

Discussion in 'Canadian Pharmacy Reviews' started by Kamikadze_666, 27-Aug-2019.

  1. hafobaka Moderator

    Tamoxifen and sleep


    Your tamoxifen may not work as well at preventing your breast cancer from returning. Taking amiodarone or thioridazine with tamoxifen may increase your risk of an irregular heartbeat, which may be life-threatening. doctor or pharmacist) know that you are using these products together. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Get less than the recommended seven hours a night – or mess up your circadian clock through, say, night shift work -- and you put yourself at risk for all kinds of health issues: high blood pressure, heart disease, diabetes, depression, obesity, lowered immunity and yes, even cancer. Now, a new study by public health researchers at Fred Hutchinson Cancer Research Center suggests sleep isn’t just important for overall health – it may also improve your chances of breast cancer survival. Amanda Phipps, who presented her findings Wednesday at SLEEP 2015, the annual meeting of the Associated Professional Sleep Societies, found an association between women who died of breast cancer and poor sleep pre-diagnosis. “The women who told us they slept less than five hours a night on average [before their diagnosis] had about a 1.5-fold increased risk of dying from their disease compared to women with breast cancer who said they slept the recommended seven to eight hours a night,” said Phipps, who used data from approximately 7,500 Women’s Health Initiative study participants diagnosed with breast cancer for her analysis. “And women who weren’t getting enough sleep and were snoring were about twice as likely to die from their disease.” Phipps emphasized that the study did not look at sleep patterns after diagnosis, when many women regularly lose sleep due to stress and other factors. “We were looking at general lifetime patterns,” she said. “We know that when a woman is diagnosed there’s a lot of stress and anxiety and treatment side effects, all of which have a bearing on sleep quality.” Study co-author and sleep expert Dr. Nathaniel Watson, a professor of neurology at the University of Washington and president of the American Academy of Sleep Medicine, also noted that even though the women who died had “extreme sleep deprivation,” it was too early to say poor sleep before a cancer diagnosis was what directly led to their death. “You don’t have enough evidence to say that it’s a cause.” Both researchers hoped the first-of-its-kind study would inspire further research in the area of sleep and cancer survival and motivate cancer survivors – and others -- to focus on good sleep habits in much the same way they focus on diet and exercise.

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    Tiny lipid bubbles packed with melatonin make tamoxifen more effective. Tamoxifen can slow tumor progression and reduce the risk of recurrence. Unfortunately, it may also induce insomnia and sleep-disrupting hot. Jul 16, 2018. Insomnia, or trouble sleeping, is a common problem for patients with cancer. Insomnia can also affect patients after being treated for cancer.

    Tiny bubbles filled with the sleep hormone melatonin can make breast cancer treatment more effective, which means people need a lower dose, giving them less severe side effects. In a new study published in , researchers show that the bubbles, called nanostructured lipid carriers (NLCs), made tamoxifen stronger and help it kill cancer cells. The authors of the study, from Tabriz University of Medical Sciences in Iran, say using NLCs packed with melatonin could also help avoid the cancer cells growing resistant to the treatment, so it will remain effective. According to the Centers for Disease Control and Prevention (CDC), breast cancer is the most common cancer in women; more than 224,000 people were diagnosed with breast cancer in 2012 in the US alone. The leading medication used to treat breast cancer is a drug called tamoxifen, which stops breast cells from growing. Despite its popularity, tamoxifen has some serious side effects. It can increase the risk of uterine cancer, stroke, pulmonary embolism and can cause vision problems. Tamoxifen resistance increases due to depleted levels of the sleep hormone melatonin. Women working night-shifts may therefore be at a risk of breast cancer, due to low levels of melatonin in their body. Tamoxifen is a standard treatment option for patients fighting breast cancer. But many patients with advanced carcinomas fail to respond to the drug. While the mechanisms that lead to this resistance are not fully understood, a new research suggests that night time exposure to light halts the production of the hormone melatonin thus making breast cancer tumors completely resistant to tamoxifen. The study titled "Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer," is the first ever to show that melatonin production is necessary for tamoxifen to work in breast cancer therapy. The study was conducted by researchers at Tulane University School of Medicine cancer researchers and published in the journal The effectiveness of melatonin in aiding the cancer killing effect of tamoxifen was demonstrated by researchers on rats which had been implanted with human breast cancer cells.

    Tamoxifen and sleep

    Tamoxifen Reviews & Ratings at, Why Sleep Problems and Breast Cancer Don't Mix Well

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    • Sleep Problems Insomnia in the Cancer Patient OncoLink.
    • Is Tamoxifen Working for You? – New Focus Daily.

    Poor sleep is a common trend among breast cancer patients. “And hormone medications like tamoxifen and aromatase inhibitors also cause. Tamoxifen has been used for several years to treat breast cancer which is hormone receptor-positive. This is because of its ability to competitively block estrogen. Lights Out Sleep, Sugar, and Survival 8601300364629 T. S. Wiley, Bent Formby Books

     
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